The List involves: Chloroquine Which is Used to Treat Malaria
About 70 medications and laboratory compounds might be efficient in using the coronavirus, a team of researchers reported on Sunday night.
A few of the medications are now used to treat other infections, and repurposing them to cure Coronavirus, the illness caused by the coronavirus, may be faster than trying to invent a new antiviral from scratch, the scientists said.
The list of drug candidates appeared in a study published on the web site bioRxiv. The researchers have offered the paper to a review for publication.
To get up with the list, a number of researchers started on an important examination of the genes of the coronavirus, also named SARS-CoV-2.
To poison a lung cell, the coronavirus should enter its genes, co-opting the cell’s individual genetic means. The cell starts to create viral proteins, which are related to create millions of new viruses.
All of those viral proteins could be able to lock onto the important human proteins for the method to work.
In the new research, the specialists examined 26 of the coronavirus’s 29 genes, which direct product of the viral proteins. The researchers discovered 332 human proteins aimed at the coronavirus.
Some viral proteins appeared to aim just one human protein; other viral proteins are able to aim a dozen human cellular proteins.
The doctors attempted remedies that also lock onto the human proteins that the coronavirus appears to want to start and replicate in human cells. The company finally recognized 24 medications approved by the Food and Drug Administration to cure such apparently independent illnesses as cancer, Parkinson’s disease, and hypertension.
Apparently, on the list are such wonderful candidates as haloperidol, used to treat schizophrenia, and metformin, practiced by people with Type 2 diabetes.
The researchers also found competitors among compounds that are now in clinical tests or that are the problem of early research. And also intriguingly, some of the possible cures are medications used to combat parasites.
The list involves antibiotics that destroy bacteria by gumming up the cellular engine they use to produce proteins. But some of those medications also add to human proteins. The new research suggests the probability that side effects may turn out to be an antiviral cure.
Chloroquine, a drug on the list, decimates the single-celled parasite that makes malaria. Doctors have long comprehended that it could also add to a human cellular protein named the sigma-1 receptor that is also the aim of the virus.
Chloroquine is much in the news last week, thanks to consideration about its performance against the coronavirus — some of which was reissued by President Trump at a news announcement at the White House on Friday.
Dr. Anthony Fauci, the director of the National Institute of Allergy and Infectious Diseases, supported the president’s comments with a notice that there was the only evidence that chloroquine may work.
Just a well-run test can confirm if chloroquine was safe and powerful against the coronavirus.
It would start a test on chloroquine, among other remedies.
The state obtained a large quantity of chloroquine and the antibiotic azithromycin to make its individual drug analysis, Gov. Andrew M. Cuomo of New York announced.