Treatment of Coronavirus, Found? Could This be the Cure for Coronavirus?

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Coronavirus Treatment or Cure, is it possible?

Vitamin C could be the cure of Coronavirus?
Vitamin C could be the cure of Coronavirus?

That column includes notes from an exclusive webinar presented to healthcare experts on March 25, 2020.  The central message in the presentation highlighted the oral form of ascorbic acid is a redox molecule that cannot be replaced by other antioxidants, perhaps even sodium ascorbate.  The mixture of high-dose oral ascorbic acid together with intravenous sodium ascorbate can significantly decrease the exponential increase of Coronavirus patients who need intense care cure after contamination.

This column also combines a recently released research that recognized the exact mechanisms used by SARS-CoV2 to damage hemoglobin, resulting in cell-free heme that increases Acute respiratory distress syndrome (ARDS).

Coronavirus, ARDS, Cell-Free Hemoglobin The Ascorbic Acid Connection

The oral form of ascorbic acid must be used to reduce Coronavirus symptoms, especially lethal ARDS, acute respiratory distress syndrome.

Most people think all the different forms of Vitamin C are the same. They are not. This difference can mean life or death in Coronavirus infected patients.

Acute Respiratory Distress Syndrome

  • Increased ARDS in Coronavirus patients overwhelms healthcare systems
  • 41.8% of COVID-19 patients develop ARDS’
  • Half of critical ARDS patients die
  • SARS-CoV2 Spike Protein Binds to ACE2 Receptors2 ACE2 concentrated in AT2 (type II alveolar cells) AT2 increase viral reproduction and transmission
  • Furin Enzymes activate SARS-CoV2

Critically ill Coronavirus patients often develop acute respiratory distress syndrome (ARDS). When that happens, intubation and invasive mechanical ventilation are required to help difficulty in breathing. Common ARDS symptoms involve the fast accumulation of fluid in the airspace, leading to edema and inflammation.

Why ARDS Develop So Quick?

SARS-CoV2 that causes Coronavirus binds to receptors for ACE2 (Angiotensin-converting enzyme 2). ACE2 receptor expression is concentrated in a small population of type II alveolar cells (AT2) in the lungs. The main problem is, AT2 also expresses many other genes that increase viral reproduction and transmission. This means once SARS-CoV2 is activated in the lungs, the patient can deteriorate so fast, and if they do not have enough ascorbic acid, they may progress to ARDS.

Why is Ascorbic Acid Important?

SARS-CoV-2 virus needs to be activated at the cleavage site in spike proteins. This cleavage site uses Turin enzymes. This is the beginning of the story where SARS-CoV2 and ascorbic acid become enemies.

Stop ARDS Now

As of March 25, 2020 :
• 30,000 Coronavirus cases in New York

• NY morgues expected to reach capacity in one week

• 40,000 will be in ICU in about 2 weeks

• NY hospitals are now using Vitamin C to treat COVID-19 patients2

Hospitals all around the world, especially those in China, are using IV C for Coronavirus because it is extremely effective.

However, my recent research revealed that Vitamin C in the form of ascorbic acid may actually prevent Coronavirus patients from developing ARDS.

This is currently the number one priority for all healthcare systems around the world — how to reduce ARDS patient load in the ICU.

IV C is Extremely Effective for ARDS Patients

  • IV C uses sodium ascorbate (SA)
  • Liposomal Vitamin C is mostly in the form of sodium ascorbate
  • IV C can shorten the length of hospital stay and speed recovery

Intravenous delivery of Vitamin C must be buffered to match physiological pH. Most standard intravenous solutions use sodium ascorbate, which is ascorbic acid combined with sodium carbonate. The pH of pure ascorbic acid is too low for plasma delivery.

Many people cannot tolerate ascorbic acid and thus use liposomal forms. Most commercially available liposomal Vitamin C uses the sodium ascorbate form of Vitamin C.

The question is, can sodium ascorbate prevent COVID-19 patients from developing ARDS?

Ascorbic Acid versus Sodium Ascorbate
• Ascorbic acid has a different molecular structure from Sodium ascorbate

When sodium bicarbonate is added to ascorbic acid, the parent molecule changes its molecular structure and becomes sodium ascorbate.

Sodium ascorbate has 6 carbon, 7 hydrogen, 6 oxygen, and one sodium atom that replaces the 8th hydrogen in its parent.

The addition of the sodium ion makes this molecule more reactive and less stable than its parent, ascorbic acid.

Thus, it is actually ‘better’ as an antioxidant, but this also makes it less suitable as a REDOX molecule.

Why?

REDOX reactions always involve a pair of molecules; one accepts an electron, the other donates an electron.

The energy of REDOX is measured in electron volts. One electron volt = 1000 mV.

The lower (more negative) the voltage, the easier it is for the molecule to give up or lose its electrons. The higher (more positive) the voltage, the easier it is for the molecule to grab or gain electrons.

Oxidants have high reduction potentials, with large positive numbers. Antioxidants are the exact opposite. They have low reduction potentials with large negative numbers.

When you compare ascorbic acid with a standard antioxidant like glutathione, you will see why ascorbic acid is really not a powerful antioxidant.

Ascorbic acid reduction potential is + 0.282 eV; Glutathione is – 240 mV at pH 7.0

Between ascorbic acid and glutathione, there is a huge difference of 522 mV, or more than half an electron volt. Therefore, compared to glutathione, ascorbic acid is quite stable and interactive.

Ascorbic acid can be regenerated (reduced) by NADH, NADPH, and Glutathione. Due to the low reduction potentials of these molecules, NADH, NADPH and Glutathione are all powerful antioxidants.

NADPH has a lower reduction potential than glutathione; that is why NADPH is used to regenerate (reduce) glutathione.

Cell-free hemoglobin is unstable heme within hemoglobin with oxidized ferric iron centers. They bind to proteins and lipids, causing inflammatory free radical chain reactions such as lipid peroxidation.

Healthy endothelial cells maintain tight barriers that limit permeability. CFH decreases intracellular ascorbate. CFH increases permeability inducing loss of barrier function that allows the passage of large macromolecules.

A new study released on March 23, 2020, revealed the STARTLING MECHANISMS used by SARS-CoV2 to create Cell-Free Hemoglobin and Induce ARDS Coronavirus: Attacks the I-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism

  • IV C is an indispensable tool in the fight against ARDS in Coronavirus.
  • IV C provides a continuous stream of electrons from sodium ascorbate that can regenerate haptoglobin.
  • Haptoglobin is used by the body to bind cell-free hemoglobin.
  • Haptoglobin is dependent upon antioxidants to supply electrons to reduce ferric iron in order to maintain heme in a stable form.
  • Haptoglobin is not specific to ascorbic acid.

When IV C is used to treat Coronavirus patients, it will free oral ascorbic acid to support critical cellular redox reactions. Ascorbic acid reduces ferric iron to inhibit the formation of cell-free hemoglobin. Reduced CFH will lower the destruction of nitric oxide. Nitric oxide homeostasis supports immune functions.

Adequate oral ascorbic acid will protect mitochondria from cytotoxic effects of depolarization caused by viroporins. Ascorbic acid can also elevate lymphocytes, neutrophils, and natural killer cells, helping to defeat Coronavirus infection.

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